Alpha Phi Omega in the United States organizes the country into eleven geographical regions numbered from east to west. Chapters within each region elect a Region Director at the national convention to represent them on the National
. Regions are further divided into
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| Region I | Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, Rhode Island and Providence Plantations, Vermont, and the counties to the southeast of Dutchess and Orange in New York. | View Details |
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| Region II | Delaware, New York (counties including and to the northwest of Columbia, Sullivan and Ulster), and Pennsylvania (all counties including and to the east of Bedford, Blair, Centre, Clinton and Potter). | View Details |
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| Region III | District of Columbia, Maryland, North Carolina and Virginia. | View Details |
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| Region IV | Alabama, Florida, Georgia, Puerto Rico, South Carolina, Tennessee, all U.S. Caribbean territories, and Kentucky (all counties including and to the west of Adair, Breckinridge, Grayson, Green, Hart, Russell and Wayne). | View Details |
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| Region V | Ohio, West Virginia, Kentucky (all counties including and to the east of Casey, Hardin, Larue, Meade, McCreary, Pulaski and Taylor), and Pennsylvania (all counties including and to the west of Cambria, Cameron, Clearfield, McKean and Somerset). | View Details |
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| Region VI | Indiana, Michigan, and Illinois (except the following counties: Madison, Monroe, Randolph, St. Clair, Bond, Fayette, Clinton, Marion, Washington, Jefferson, Perry, Franklin, Jackson, Williamson, Union, Johnson, Alexander, Pulaski, and Massac). | View Details |
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| Region VII | Louisiana, Mississippi, New Mexico, and Texas. | View Details |
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| Region VIII | Arkansas, Colorado, Kansas, Missouri, Nebraska, Oklahoma, Wyoming, and some counties in Illinois (Madison, Monroe, Randolph, St. Clair, Bond, Fayette, Clinton, Marion, Washington, Jefferson, Perry, Franklin, Jackson, Williamson, Union, Johnson, Alexander, Pulaski, and Massac). | View Details |
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| Region IX | Iowa, Minnesota, North Dakota, South Dakota and Wisconsin. | View Details |
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| Region X | Arizona, California, Hawaii, Nevada, Utah, the Northern Marianas Islands, and all U.S. Pacific territories. | View Details |
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| Region XI | Alaska, Idaho, Montana, Oregon and Washington. | View Details |
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